Tag Archives: Genetics/Epigenetics

Posts about genetics and epigenetics.

What Does Random Mean?

What Does Random Mean?

I’ve been reading a lot of articles about scientific journalism, and what Scientists and Journalists need to change in how they release new findings to combat public misunderstanding. There are some great ideas there, and a lot of people committed to making this happen. The problem, though, is that science has a lot of concepts and vocabulary that are either exclusive to science (and impossible for non-scientists to understand) or are used differently in a colloquial context. So I’m going to start small and pick one. RANDOM.

If you’re having a conversation with someone and the word “random” comes up, you’re likely to think “something completely unexpected,” or “something without precedent,” or “something that just makes no sense.” “Random” started off meaning one thing to scientists and mathematicians and another to everyone else, and now it’s becoming a catchword for many other things that are even further removed from the strictest definition of “random.” Pseudoscientists and peddlers of dubious ideas and products take advantage of this by using the new popular understanding of the word to misrepresent or even mock science that uses it, so I want to set you straight.

Let’s start off with a straightforward explanation. “Random,” in science or mathematics, refers to a set or subset of existing things that is separated, combined, or put in order without any plan or pattern.

Take a look at A Million Random Digits with 100,000 Normal Deviates. This book has been around for a long time, and it’s an important tool for checking probabilities and mathematical formulae to make sure that they work with numbers that have no patterns. It’s not a very exciting read, obviously, but what you will find if you look at it is pages and pages of numbers. In other words, you will not find symbols, color dots, letters, or little drawings of cats. The numbers are random because they cannot be placed in any kind of sequence – as a simple example, you wouldn’t be able to add three to the first digit, six to the next, nine to the next pair, etc.

If you were talking to your friend about this book of numbers that was, like, totally random, your friend might reasonably expect to find those symbols, color dots, letters, or little drawings of cats. But your friend would be wrong; that wouldn’t truly be random since none of those things exist in the set called “numbers.”

So let’s look at this from the point where I see most of the misinterpretation of “random”. . .genetics. I want you to imagine two bags of marbles. I’m not going to specify how many, because we’re not going to get started on the difference between chromosomes and genes or anything like that. We’re just going to be very general and say that each marble represents a piece of genetic information.

two-sacks

One sack is filled with marbles that represent Dad’s genetic information, the other is filled with marbles that represent Mom’s genetic information. Now let’s say that Dad’s marbles are almost all primary colors, but there are a couple of purples, a few greens, one black, and one white. Mom’s marbles are mostly secondary colors, but she does have a smattering of reds, blues, and yellows, and one black and one white. So you reach into the bags blindfolded and grab a handful of each, and this is what you come up with:

two-sets-of-marbles

That’s random (although it’s unlikely that you’re going to get the single black marble and single white marble from each bag. I just wanted to use them.) Do you see any peach pits, or rocks, or silver marbles? Of course not. They weren’t part of the set from which you were randomly selecting. They’re not going to appear out of nowhere – and if they do, it’s not scientifically random.

Now let’s say that we’re going to pair them up. The only rule is going to be that the marble from Dad’s set can’t be paired up with the same color from Mom’s set. In real life, this happens fast, and the number of pairs is significantly bigger, but this is a decent symbolic representation. So across the top are the marbles we got from Dad, and below that are the marbles we got from Mom.

marbles-paired

Randomly we ended up with a unique combination – but still, there is nothing there that wasn’t present in the original set. Randomly we ended up with an extra blue marble from Mom. It could have been an extra orange, purple, green, red, yellow, black, or white marble – but it could never be a peach pit, or a rock, or a silver marble.

You could take all these marbles and put them in different sequences, but nothing is going to change the number of marbles, the colors, or which marbles came from which bag. You might get different pairs of colors, or all the same pairs but in different order.

Randomness, in science or mathematics, means that we have certain things that are givens. A set of numbers will contain nothing but numbers. A set of genes will contain nothing that isn’t already in the genome. Any random thing we look at will be comprised of something very specific that already exists. What makes it random is how it ends up being put together.

I hope that makes sense. Feel free to ask questions or add to the discussion.

Wednesday Links

Wednesday Links

A new study was published in the Journal of the American Medical Association about neuroimaging to determine response to medication or therapy in Major Depressive Disorder. It seems much more exciting if you don’t actually read it. Fortunately, Neurocritic did, so you have someone to explain what’s hope and what’s hype.

Paul Offit explains why we shouldn’t take multivitamins.

He also has a book coming out soon called “Do You Believe in Magic? The Sense and Nonsense of Alternative Medicine” and USA Today covers some of the issues that make this stuff such a dangerous alternative.

And Darshak Sanghavi at Slate wonders why so many of us think we need to avoid gluten

Now, if you happen to be near Washington, DC, and you want to see some cool genetics stuff, hit the Smithsonian Museum of Natural History for an exhibit called Genome: Unlocking Life’s Code.

Teaching otters to use vending machines might not be the best idea, but it sure is cute to watch.

Wednesday Links

Wednesday Links

Yes, it’s been a while since the last set of links. I’ll try to do better. Enjoy these for now.

Carl Zimmer wrote an article on Fibrodysplasia Ossificans Progressiva for the Atlantic. One of the reasons I think it’s important to read stories like these is to see examples of the success that comes from investigating genetic origins of diseases. Another is to show that there are real reasons that a treatment may or may not be produced outside of the simple profitability of the treatment itself. All in all, this is a great story with some human interest thrown in for good measure.

I’ve often had the discussion with people about how even though we have names for colors, not everyone perceives them the same way. Well. . .who’d have known it? Apparently some of our perception differences arise from how we name the colors in the first place! Empirical Zeal discusses it in two parts. Part 1. Part 2.

Beyond Recognition: The Incredible Story of a Face Transplant
Yes, it’s graphic, but it’s also absolutely amazing.

Scicurious has an interesting piece about genes and environment. . .interesting not only because it shows an actual mechanistic result in the brain that can differentiate genetically identical mice, but also because those of us on SSRIs can take comfort in knowing our meds are assisting us in hippocampal neurogenesis.

Another thing that seems to be related to a mechanical malfunction in the brain is Body Integrity Identity Disorder, in which a person is uncomfortable with the very presence of a part of his or her body. Mindscapes: The man who needs to paralyse himself in New Scientist talks about some of the possible roots of this condition that makes people seek elective amputation procedures.

From Nature, an explanation of what a chemical is, and why it’s not inherently dangerous or toxic.

Some tips
on distinguishing science journalism from infotainment.

And. . .a tap-dancing seagull.